The following month, it was announced that Brad Abrell had replaced Kevin James as the voice of Frankenstein. The role was given to Brian Hull after voicing the character in the short film Monster Pets, while Kathryn Hahn, Steve Buscemi, David Spade, and Keegan-Michael Key were confirmed to reprise their roles. That same month, Sony confirmed that Adam Sandler would not reprise his role as Dracula. In April 2021, the film's title was revealed to be Hotel Transylvania: Transformania and was confirmed that it would be the final film of the series. Production took place remotely during the COVID-19 pandemic.
In September 2020, Jennifer Kluska and Derek Drymon, a storyboard artist on the first two Hotel Transylvania sequels and a former crew member of SpongeBob SquarePants and Adventure Time, respectively, were confirmed to be the film's directors, while Tartakovsky would write the screenplay and serve as an executive producer alongside Selena Gomez, who voices Mavis in the series. In October 2019, Genndy Tartakovsky confirmed that he would not direct the film. In February 2019, Sony Pictures Animation announced that a fourth film had been in development. Richard Tyler Blevins as Party Monster.